Research detects the anti-inflammatory effect of MiS on cells and molecules

12 April 2021 - Research -
Share

ASAcampus is constantly at the forefront in developing new research. The latest is “Effect of NIR Laser Therapy by MLS‐MiS Source on Fibroblast Activation by Inflammatory Cytokines in Relation to Wound Healing” che si which aimed to study the anti-inflammatory activity of MiS, the ASA device capable of combining the synchronised action of MLS® Laser Therapy with the pulse power of Hilterapia®, from the cellular and molecular point of view.

The in-vitro study was carried out on human dermal fibroblasts exposed firstly to a mix of inflammatory cytokines (IL‐1β and TNF‐α) which subsequently underwent treatment with MiS.

Three types of samples were analysed:

  • the first concerned human fibroblasts stimulated with IL‐1β and TNF‐α for 48 hours which subsequently underwent 3 laser treatments (once a day for 4 consecutive days);
  • the second envisaged a similar stimulation mix, but avoided exposure to the laser;
  • the third neither underwent stimulation, nor laser.

After analysing the results, the researchers noted that the main pathways signalling inflammation were increased (or activated) by the mix of cytokines, whilst treatment with MiS lowered the levels, restoring basal levels, in a statistically significant manner.  The same was noted when assessing the VEGF levels (the factor involved in neovascularisation of granular tissue).

The research also allowed analysing some of the most important cytoskeletal proteins which had modified their organisation after stimulation with cytokines, and returned to the basal distribution after treatment with MiS.

It can therefore be concluded that not only does the ASA device have an important anti-inflammatory effect, but it is also effective in controlling fibroblast activation induced by IL‐1β and TNF‐α, probably responsible for a detrimental effect on the inflammation’s evolution, which favours its persistence.
 

You might also be interested in ...

See all articles

ASA Research Division
Successful Cases - 26/03/2020
There is a close connection between the growth of ASA and the scientific production in the biomedical field. Since its inception, the company understood how important a role research would play in...
myelin thickness with MLS laser MiS
Research
L. Micheli, F. Cialdai, A. Pacini, J.J.V. Branca, L. Morbidelli, V. Ciccone, E. Lucarini, C. Ghelardini, M. Monici, L. Di Cesare Mannelli Nature Scientific Reports, 9:9297, 2019
MiS handpieces
Research
S. Genah, F. Cialdai, V. Ciccone, E. Sereni, L. Morbidelli, M. Monici Biomedicines 9, 307, 2021 The present study demonstrates that the proposed NIR laser therapy is effective in controlling...
Press - 03/05/2021
Every week, approximately 6 out of 10 Italians have to deal with back pain which limits their daily activities: Laser Therapy (MLS® and Hilterapia®) combined with postural gymnastics is successfully...
Press - 21/04/2021
The financial section of the daily newspaper “Il Giornale di Vicenza” devotes an extensive focus to the valuable results chalked up by ASA for the first quarter of 2021.
ASA laser device manufacturing
News - 20/04/2021
Breaking through 3 million euro in turnover, ASA marks an excellent result for the first 3 months of activity of 2021 thanks to a significant increase in the sales of its therapies for the human and...