MLS®: efficacy and safety in the prevention of radiodermatitis in women with breast cancer

16 February 2023 - Research -
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Two recently published studies conducted by PhD Jolien Robijns – already the team leader in several research projects on the efficacy and safety of treatment with photobiomodulation (PBMT) in the prevention of side effects related to radiotherapy and chemotherapy - have investigated the efficacy of MLS® Laser Therapy in the prevention of acute radiodermatitis in patients with breast cancer undergoing hypofractionated radiotherapy and in the long-term safety of the treatment in patients treated with conventional fractionated radiotherapy.

The first study, a randomised controlled multicentre LABRA-trial, involved 86 patients divided into two groups. The control group received a standard topical skin treatment while the treatment group additionally received MLS® Laser Therapy with the M6 device for 4 weeks. The results showed a lower incidence of acute radiodermatitis and wet desquamation in the PBMT group than in the control group.

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Lasers in Surgery and Medicine - Journal

“Photobiomodulation therapy for the prevention of acute radiation dermatitis in breast cancer patients undergoing hypofractioned whole-breast irradiation (LABRA trial).” 
Robijns, Jolien et al. 
Lasers in surgery and medicine vol. 54,3 (2022): 374-383. doi:10.1002/lsm.23475

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The second research, an extension of the previous TRANSDERMIS-trial, validated the safety 5 years after treatment with MLS® Laser Therapy, applied for the prevention of radiodermatitis. There was no significant difference between the group of patients treated with MLS® Laser Therapy compared with the untreated ones in terms of locoregional recurrences (DFS - disease‐free survival), development of new primary tumours (CFS - cancer‐free survival) or survival in general (OS - overall survival). Patients were monitored every six months from April 2015 to May 2022 by means of clinical evaluation, blood tests and mammography.

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Lasers in Surgery and Medicine - Journal

“A long-term follow-up of early breast cancer patients treated with photobiomodulation during conventional fractionation radiotherapy in the prevention of acute radiation dermatitis.” 
Robijns, Jolien et al. 
Lasers in surgery and medicine vol. 54,10 (2022): 1261-1268. doi:10.1002/lsm.23608

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