MLS® in Veterinary Medicine: New Clinical Evidence from Canine osteoarthritis to Equine Traumatic Injuries

07 April 2026 - Research -

New scientific evidence supports the use of ASAveterinary's MLS® technology in the management of complex musculoskeletal disorders in veterinary medicine. Two studies, conducted in collaboration with the University of Naples Federico II and the University of Padua, show significant results in the management of canine osteoarthritis and traumatic limb injuries in horses.

New research focuses on MLS® Laser Therapy by ASAveterinary (the veterinary division of ASA, a Vicenza-based company specialising in the production of laser therapy and magnetotherapy devices for veterinary and human use), highlighting its effective use in the treatment of particularly complex conditions in dogs and horses. The studies, conducted in collaboration with the University of Padua and the University of Naples Federico II, highlight how MLS® technology can be integrated into multimodal therapeutic approaches. The integration of clinical practice, academic research, and technological development is indicative of the growing role that photobiomodulation currently holds in modern veterinary medicine, thus opening up new perspectives in pain management and tissue repair processes.

Canine osteoarthritis defeated thanks to laser acupuncture with the MLS® system

The study conducted by the University of Naples Federico II 

A randomised controlled clinical trial published in the scientific journal Animals (2025) and conducted by the Department of Veterinary Medicine at the University of Naples Federico II evaluated the efficacy of laser acupuncture with the MLS® system in the treatment of canine osteoarthritis.
The trial, conducted on 19 dogs with severe osteoarthritis, revealed a significant improvement in joint mobility and a reduction in pain compared to the control group.

“Following this randomised clinical study in the treatment of severe osteoarthritis in 19 dogs, laser acupuncture with the MLS® system has been confirmed as a non-invasive, well-tolerated, and patient-specific treatment. The therapy has proven particularly beneficial in managing chronic pain associated with osteoarthritis, especially when the use of anti-inflammatory drugs is limited by contraindications or potential side effects. Its efficacy appears to be linked to a combination of multiple factors that enhance its therapeutic effect: on the one hand, the synergy between continuous and synchronised pulsed emissions allows for deep tissue penetration; on the other, the treatment combines analgesic, anti-inflammatory, and anti-oedema effects with improved cellular metabolism, microcirculation, and fluid drainage”, explains Dr. Claudia Gatta from the Federico II University of Naples, who conducted the study together with Prof. Giovanni Della Valle, Dr. Federica Aragosa, and Dr. Giovanna Calzaretta. 

The latter was also a speaker at the sold-out course “Laser puncture in Veterinary Medicine”, held at the ASA headquarters and open to veterinarians from all over Italy. The course focused on the application protocols for the devices developed by the company.

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Laser Acupuncture Effects on Chronic Pain, Inflammatory Response, and Biochemical and Oxidative Stress Markers in Osteoarthritic Dogs: A Randomized Controlled Trial
C. Gatta, G. Calzaretta, N. Musco, F. Aragosa, S. Cavalli, S. Damiano, P. Lombardi, A. Ferrentino, D. Lotito, G. Della Valle, M.E. Pero
Animals, 15(17):2568, 2025

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Traumatic distal limb injuries in horses

The benefits of high-power photobiomodulation in conservative protocols in research conducted by the University of Padua

A second study published in Large Animal Review (2025) also highlights the value of MLS®. It describes the conservative management of two severe traumatic limb injuries in horses using a multimodal protocol integrated with high-power photobiomodulation.
The two cases analysed concerned a complete laceration of the flexor tendons involving the synovial sheath and an avulsion of the hoof wall with exposure of the distal phalanx.
The research, the result of a series of field cases collected by Dr. Ilaria Grossi (DMV horse doctor) and subsequently developed in collaboration with Dr. Giulia Forni (DMV) from the University of Padua, showed how the use of high-power photobiomodulation in conservative protocols resulted in progressive tissue repair and functional recovery of the limb in both cases, without infectious complications.

“The ability of photobiomodulation therapy to regulate biological processes – comments Giulia Forni, who was supported by the ASA clinical department in conducting her research - is certainly the reason for the growing interest in this technology in Veterinary Medicine. In particular, by reducing local inflammation and stimulating tissue repair, it proves to be a particularly useful aid in cases, such as those presented in the article, where treatments considered the gold standard in the literature cannot be used for various reasons. The healing rate was objectively faster than previously documented. Furthermore, another aspect to consider, especially for those working with large animals, is the animals' high tolerance to the treatment.

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Large Animal Review

High-power Photobiomodulation Therapy in the Conservative Management of Two Severe Equine Distal Limb Injuries
I. Grossi, D. Travalin, G. Forni
Large Animal Review, 31:415-420, 2025

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